Hematologic toxicity is increased at higher doses and in patients with elevated baseline liver function tests. O 0. So far no nausea, neuropathy, pain, fatigue or major side effects. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Contact your doctor if you experience these side effects and they are severe or bothersome. Docetaxel forum. Available for Android and iOS devices. VAT no: 668265007, Planned maintenance - Tuesday 10th November, 7am-1pm, Fixes and issues - an update for members, October 2020. Pharmacokinetics. Tramodol can make your mood feel worse. Low Levels Of A Type Of White Blood Cell Called Neutrophils 7. Docetaxel administered intravenously over 1–2 hours has linear pharmacokinetics and the AUC increases proportionately with dose [117 R].Plasma protein binding is 76–89% [118 R].The half-life is 11 hours. 2 months ago. 3. They all cause constipation and that would be my first guess for any stomach or gut discomfort. I used DHC dihydrocodeine (spell?). Your pharmacist may be able to advise you on managing side effects. morning Amanda, shame about the works 'do' I managed to go to ours last year, although my feet felt like they were actually burning by the end of the evening. I think I'll try and go for an hour later. I am days 3 post docetaxel/carboplatin chemotherapy. Hope you are feeling well. Happy to speak Welsh if you'd prefer. Microtubules are part of th .. More information can be found on chemocare.com and cancer.gov . [Ref], Severe hypersensitivity reactions have been reported. Sounds all very normal and common SE of docetaxol. Radiation is out because of its location (left, over heart). Do not use patients with neutrophil counts of less than 1500 cells/mm(3); obtain frequent blood counts to monitor for neutropenia. Abnormal Peeling Of Skin 4. The following side effects are common (occurring in greater than 30%) for patients taking docetaxel: Low white blood cell count. That's what it felt like anyway. Taxotere (docetaxel) works similarly to many chemotherapy medications by disrupting cell division (called mitosis). Praying this regime works on my tumor. I had tingling in my feet and finger tips. Hospira Inc, Lake Forest, IL. Xx. Fingers crossed it goes well for you too. The chemo itself isn’t as bad as what he thinks it will be, the fear of it is understandable but it has made a difference for us. What's next for the Online Community? Breast cancer forum requires membership for participation - click to join. No doubt it's working hard at the mo. I felt crap from around day three post tax until 7-9 days. You wouldn't feel up to it but I can recommend walking daily. Side effects were fatigue, a small rash would pop up on a different body part after each infusion but disappeared with just good moisturizer applied. Just keep in mind it's doing its job and for a positive outcome and I hope you get through this period as painfree as possible xxx. Thankful the first round was the worst & they got progressively easier. Severe fluid retention may occur despite dexamethasone. Docetaxel (DOCEtaxel)." Although not all of these side effects may occur, if they do occur they may need medical attention. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Am drinking tons of water so that should be helping the old liver function. Increases in AST and/or ALT to greater than 1.5 x ULN concurrently with alkaline phosphatase elevations to greater than 2.5 x ULN occurred in 4.3% of patients. An Infection 3. Severe stomatitis has been reported in 6% of patients with normal LFTs at baseline and 13% of patients with elevated LFTs. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to docetaxel: intravenous powder for injection, intravenous solution, The most common adverse reactions across all indications include infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin reactions, and myalgia. Avinash Gupta, Mark Middleton, in Side Effects of Drugs Annual, 2011. Frequency not reported: Paresthesia, dysesthesia, neuromotor weakness, Postmarketing reports: Confusion, seizures or transient loss of consciousness[Ref], The cumulative risk of developing treatment-related acute myeloid leukemia appears to be similar to the risk observed for other anthracyclines/cyclophosphamide containing adjuvant breast chemotherapy regimens. Least it's Friday! 5. The therapies and drugs patients are talking about to alleviate themselves from side effects of docetaxel. Elimination is mainly by biliary excretion into the feces [119 R]. So surprised, as I coped really well with the EC, that the Docetaxel has knocked me flat. Please support our emergency appeal. Could hardly walk. • Try the ideas in Fatigue/Tiredness – Patient Handout. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Metastatic castration-resistant prostate cancer (mCRPC) is a type of prostate cancer which has spread to other areas of the body and is resistant to androgen deprivation therapy (reduction of male hormones like testosterone which cause prostate cancer growth).The chemotherapy docetaxel is a first-line treatment for mCRPC.It is a cytotoxic drug, in that it can cause adverse (negative) side effects. Docetaxel is used to treat breast, prostate, stomach, head and neck and non-small cell lung cancer (NSCLC).. Absence Of Menstrual Periods 5. I may try and go for an hour later. In addition to prostate cancer, Taxotere may be used for people with some kinds of lung cancer, breast cancer, … I've had 5 doses of Docetaxel now, 6th and final one coming up next Thursday. I have NSCLC stage 4. Since cancer cells are some of the most rapidly dividing cells in the body, these cells are preferentially affected by the action of Taxotere and, consequently, die at high rates when the drug is administered. What are other peoples experiences of this? My works do today but not up to going. Thanks. ------------------------------------------------------------------------------------------------------------------. A company limited by guarantee, registered in England and Wales company number 2400969. Commonly reported side effects of docetaxel include: severe neutropenia, infection, severe leukopenia, severe thrombocytopenia, neutropenia, edema, hypersensitivity condition, peripheral edema, skin rash, alopecia, anemia, arthralgia, asthenia, burning sensation, diarrhea, dysesthesia, fever, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, leukopenia, myalgia, nausea, pain, paresthesia, stomatitis, vomiting, weight gain, nail depigmentation, nail hyperpigmentation, and thinning of nails. It's been a week now though and was expecting it to start subsiding by now. I asked my oncologist about it and he explained the science behind it (I can not remember), but he also said that a few of his previous patients have sworn that Clarytin worked for them. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. O 0. I have to say that for me recovery from these side effects was less each cycle but tramadol helped! "Product Information. The most common side effects of Docetaxel may include hair loss, constipation, diarrhea, nausea and vomiting. Had 3 sessions previously of EC. Never known anything like this. Common side effects of Taxotere include: injection site reactions (pain, redness, or swelling), nausea, Decreased Blood Platelets 5. These are side effects that we have understood to be related to docetaxel for many years, so I have made adjustments. Description: Docetaxel promotes the assembly of microtubules from tubulin dimers, and inhibits the depolymerisation of tubulin which stabilizes microtubules in the cell.This results in inhibition of DNA, RNA, and protein synthesis. My body and joints ached all over, from my jaw to my ankles. Not feeling too bad now I'm dosed up and can quite imagine getting dressed and going in for an hour later. Caused trouble swallowing and chewing.” It may sometimes be used to treat other cancers. Constipation 6. My 2nd round of Taxel I found that Ibuprofen worked better than Tramodol, paracetamol, co-cordomol etc for me personally. A patient will take two pills on one day, wait a week, then do it again, for however many weeks are prescribed. What are the side effects of either one of these drugs? Commonly reported side effects of docetaxel include: severe neutropenia, infection, severe leukopenia, severe thrombocytopenia, neutropenia, edema, hypersensitivity condition, peripheral edema, skin rash, alopecia, anemia, arthralgia, asthenia, burning sensation, diarrhea, dysesthesia, fever, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, leukopenia, myalgia, … The finger and toe nails don't look so good, one finger and one toe nail look a bit dodgy, I hope I don't lose them, or … It is best to read this information with our general information about the type of cancer you have.. (This can increase your risk for infection) The most common side effects are blood disorders and fluid retention, which occurred in 64 percent to 96 percent of people in clinical trials. [Ref], Considering all tumor types, stomatitis has been reported in 42% of patients with normal LFTs at baseline and 49% of patients with elevated LFTs. The tramadol works great but you just end up feeling sleepy all the time. Infections can sometimes be life threatening. Could you manage an hour just to say hello? Well I took 2 the day before chemo lol, and 2 every day for 7 days lol, along with Ibuprofen every 4hrs. Minor events, including flushing, rash with or without pruritus, chest tightness, back pain, dyspnea, drug fever, or chills have been reported and after discontinuation of the infusion and instituting treatment as necessary, have resolved.

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